Preparation of Liposome Precursors by Supercritical Anti-solvent Techniques
نویسندگان
چکیده
The possibility of preparation of hydrogenated phosphatidylcholine (HPC) liposome precursors (LP) using supercritical anti-solvent technology (SAS) was evaluated. Vitamin D (VD) and coenzyme Q10 (CoQ10) were chosen as the model drugs, and HPC was used as the wall material. The influences of operation conditions (pressures, concentrations and etc.) on the HPC were studied. The structure of the LP was characterized by TEM. The size of the HPC and LP were also analyzed. The results show SAS can be as a simple and effective method to prepare LP. The product is in a dry form, which may solve the stability-associated problems.
منابع مشابه
Supercritical Fluid Technologies to Fabricate Proliposomes.
Proliposomes are stable drug carrier systems designed to form liposomes upon addition of an aqueous phase. In this review, current trends in the use of supercritical fluid (SCF) technologies to prepare proliposomes are discussed. SCF methods are used in pharmaceutical research and industry to address limitations associated with conventional methods of pro/liposome fabrication. The SCF solvent m...
متن کاملPreparation and Evaluation of Cyproterone Acetate Liposome for Topical Drug Delivery
Cyproterone acetate (CA) has been loaded to liposome by solvent evaporation and thin film formation technique. The effects of some formulation variables such as temperature of organic solvent evaporation, rotary evaporator speed, volume of organic solvent, volume of balloon and temperature of hydrating buffer has been evaluated. The data showed that bigger balloon with higher surface are...
متن کاملPreparation of controlled release microspheres using supercritical fluid technology for delivery of anti-inflammatory drugs.
Ethylcellulose/methylcellulose blends were produced using different precipitation techniques and impregnated with naproxen, a non-steroidal anti-inflammatory drug (NSAID). Solvent-evaporation technique was used not only for the preparation of ethylcellulose/methylcellulose microspheres but also to encapsulate naproxen. Supercritical fluid (SCF) impregnation was also performed to prepare naproxe...
متن کاملApplication of Supercritical Fluid Technology for Preparation of Drug Loaded Solid Lipid Nanoparticles
Small changes in pressure or temperature, close to the critical point, lead to large changes in solubility of supercritical carbon dioxide (CO2). Environmentally friendly supercritical CO2 is the most popular and inexpensive solvent which has been used for preparation of nanodrugs and nanocarriers in drug delivery system with supercritical fluid technology. Delivery...
متن کاملPreparation of acetazolamide composite microparticles by supercritical anti-solvent techniques.
The possibility of preparation of ophthalmic drug delivery systems using compressed anti-solvent technology was evaluated. Eudragit RS 100 and RL 100 were used as drug carriers, acetazolamide was the model drug processed. Compressed anti-solvent experiments were carried out as a semi-continuous or a batch operation from a liquid solution of polymer(s)+solute dissolved in acetone. Both technique...
متن کامل